Analysis of protein aggregation – an underlying mechanism in many diseases
PhD defence, Friday 10 February 2012. Maria Andreasen.
2012.02.03 |
Maria Andreasen
During the course of her PhD studies, Maria Andreasen carried out research into the mechanisms behind protein aggregation, a phenomenon that is closely linked with many diseases, such as Alzheimer’s disease and type 2 diabetes. When protein aggregation occurs, the proteins clump together and unnatural fibre-like structures are formed. This can damage the affected tissue, thus causing disease.
Maria Andreasen studied the aggregation of fragments of two proteins that are involved in type 2 diabetes and corneal dystrophy, respectively. Even though the symptoms of these diseases are very different, as are the affected tissues, they have one thing in common – protein aggregation. The results achieved contribute to the basic understanding of the mechanisms behind protein aggregation.
The PhD degree was completed at the Interdisciplinary Nanoscience Centre (iNANO), Science and Technology, Aarhus University.
Time: Friday 10 February 2012 at 13.00
Place: Conference Room, building 3130, room 303
Title of dissertation: Modulation of Protein Aggregation. Biophysical investigation of the fibrillation of Fas 1-4 and hIAPP20-29
Contact information: Maria Andreasen, mariaj@inano.dk
Members of the assessment committee:
Mark Krebs, Pfizer Worldwide Research and Development, USA
Associate Professor Michael Toft Overgaard, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University
Professor Jørgen Kjems (chair), iNANO and Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Daniel Otzen, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The dissertation will be defended in English
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology / GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.
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